Indeed, the top enriched Gene Ontology terms linked to oxidoreductase/nitrite reductase activity and cellular response to oxidative stress contained the 3 antioxidant genes CBS, CYB5B, and MGST1 that were found downregulated in the high plasma Lp(a) group.40–42 We validated these findings by comparing the transcriptomic profile of patients without diabetes with high versus low plasma Lp(a) to that of 57 patients without diabetes with high versus low arterial L-NAME-induced delta(O2.−). This evidence concerns the gene CYB5B and diabetes mellitus.