LPA and coronary artery disorder: This study is the first to demonstrate that plasma Lp(a) levels are associated with higher risk of cardiovascular death in patients with advanced CAD undergoing cardiac surgery, and this effect was found to be dependent on vascular O2.−, as measured in arterial biopsies at the time of surgery, highlighting the key role of vascular redox dysregulation as a link between plasma Lp(a) levels and cardiovascular risk.