We then conducted quantitative trait association tests and combined these 7 SNPs to construct a modified genetic signature of Lp(a) in this population with advanced CAD (Table S1).9 A modified LPA genetic risk score (LPA GRS) was then generated, in which patients with any alternative allele from ≥3 of these LPA SNPs (the alternative LPA GRS group) were compared with those with no alternative alleles in any of these LPA SNPs (the LPA GRS reference group). This evidence concerns the gene LPA and coronary artery disorder.