Next-generation sequencing (NGS) (Figure 1D) of the proband’s CRC tissue identified novel large deletions in EpCAM (exons 8–9) and MSH2 (exons 1–16), not previously documented in the International Society for Gastrointestinal Hereditary Tumors (InSiGHT) database. The gene discussed is EPCAM; the disease is colorectal carcinoma.