In bladder cancer, CAF‐derived CXCL12 activates the downstream JAK2/STAT3 pathway, promoting the expression of the deubiquitinase CYLD and the accumulation of p62, thereby inhibiting the autophagic degradation of PD‐L1 and inducing immune evasion [166]. The gene discussed is CD274; the disease is urinary bladder carcinoma.