CD8A and neoplasm: [135] employed clustered regularly interspaced short palindromic repeats (CRISPR)‐mediated genome‐wide editing to identify molecular determinants influencing the abscopal effect during radioimmunotherapy, discovering that CAFs exhibiting elevated secreted frizzled‐related protein 2 expression impair CD8‐positive T lymphocyte infiltration into nonirradiated tumor regions, consequently modulating distant therapeutic responses.