Second to skeletal muscles, dystrophin expression is second highest in the CNS.48 Human brain transcriptome data show that dystrophin transcripts are highly expressed in several cortical and subcortical brain regions.49 Postmortem analyses of DMD brains show that the lack of brain dystrophin leads to shorter dendritic length,50 fewer dendritic branching,50 astrogliosis,50 as well as synaptic proteomic changes.51 These morphofunctional changes may result in neural dysconnectivity in DMD. Here, DMD is linked to Duchenne muscular dystrophy.