CRC is driven by various oncologic signaling pathways, including the Wnt/β-catenin, RAS/RAF/MEK/ERK, transforming growth factor-beta (TGF-β) circuits and signal transducer and activator of transcription 3 (STAT3/Snail pathway) (Li et al. 2024). The gene discussed is SNAI1; the disease is colorectal carcinoma.