By producing reactive oxygen species (ROS), inhibiting the Wnt/β-catenin and STAT3 pathways, reversing the epithelial–mesenchymal transition (EMT), and other mechanisms, piperine has anticancer effects on colorectal cancer (CRC) models (Song et al. 2020; de Almeida et al. 2020). The gene discussed is STAT3; the disease is colorectal carcinoma.