Inflammatory and stress response pathways play crucial roles in the development and progression of CRC through signaling modules such as the Nrf2/Keap1 pathway; the NF-κB and lithocholic acid (LCA)-induced Src/epidermal growth factor receptor (EGFR) signaling pathways; and the JAK/STAT and COX2/PGE2 pathways. The gene discussed is SRC; the disease is colorectal carcinoma.