WT and P2Y4 KO mice were subjected to LAD ligation and intraperitoneally injected, or not, with the GW4869 exosome inhibitor (2.5 μg/g) 1 h before LAD ligation and 1, 3 and 5 days after LAD ligation during myocardial infarction (MI) onset. Here, P2RY4 is linked to myocardial infarction.