Further, G-CSF can upgrade the supplementary of ICAM-1, VCAM-1, and E-selectin through JAK/STAT and MAPK pathways to stimulate the endothelial cells.4 It improves leukocyte adhesion and transmigration that may result in injury to vessel walls and granulomatous infiltration, which is reported in histopathologic analysis of G-CSF induced vasculitis.4,5. This evidence concerns the gene ICAM1 and vasculitis.