Kinase-D interacting substrate of 220 kDa gene (KIDINS220: MIM*615759) has been recently identified as a causative gene for a complex form of HSP termed SINO syndrome, characterized by spastic paraplegia, intellectual disability, nystagmus, and obesity (Josifova et al., 2016). The gene discussed is KIDINS220; the disease is hereditary spastic paraplegia.