Univariate logistic regression identified 23 risk factors associated with severe postoperative complications after PPU repair, including: age, smoking history, alcohol, NSAID use, hypertension, cardiovascular disease, Arrived hospital later than 24 h, surgical approach, operation time, ulcer diameter, ASA score, nutritional score, preoperative pain score, ERAS, hospital stay, and preoperative laboratory markers (CRP, hemoglobin, albumin, PAR, creatinine, AST, ALT, PCT). This evidence concerns the gene CRP and Hypertension.