Arai C., Miyake M., Matsumoto Y., Mizote A., Yoshizane C., HanayaY., Koide K., Yamada M., Hanaya T., Arai S., Fukuda S. Trehaloseprevents adipocyte hypertrophy and mitigates insulin resistancein mice with established obesity. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.