SNCA and Parkinson disease: Accumulating lysosphingolipids in neurons can stabilizeneurotoxic alpha-synuclein oligomers (Battis et al., 2023).Prior brain autopsy studies revealed correlations betweenLysoGb3 isoform concentrations and pathological phosphorylatedalpha-synuclein as well as an negative correlationof GLA activity with levels of α-synuclein phosphorylatedat serine 129 – the pathological form of the protein thatpredominates in aggregates in PD (Nelson et al., 2018).