FOXO3 and chronic obstructive pulmonary disease: In COPD patients with rare exacerbations, a significantassociation was confirmed only for FOXO3A(rs2253310) in the dominant (Padj = 0.00001, OR = 0.48)and log-additive (Padj = 0.00001, OR = 0.5) models.The GG genotype of FOXO3A (rs2253310) (OR = 2.0995 % CI 1.53–2.88) and the A-G haplotype at rs3800231and rs2253310 loci of FOXO3A (Padj = 0.032, OR = 1.3195 % CI 1.02–1.67) were more frequent in the patientgroup.