FOXO1 and chronic obstructive pulmonary disease: The linkage disequilibrium between loci rs12585277 andrs9549240 of the FOXO1 gene (Dʹ = 0.6183, r2 = 0.429)and statistically significant differences in the pattern ofhaplotype frequency distribution of the FOXO1 genebetween the group of COPD patients and controls(P = 0.045) were revealed (Table S3).