Yao H., Chung S., Hwang J.W., Rajendrasozhan S., Sundar I.K.,Dean D.A., McBurney M.W., Guarente L., Gu W., Rönty M., KinnulaV.L., Rahman I. SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice. The gene discussed is FOXO3; the disease is pulmonary emphysema.