The comparative study of the wogonin network pharmacology against acute monocytic leukemia treatment (AML‐M5) indicated that wogonin was efficient on SRC, RELA, JUN, CCND1, TP53, HSP90AA1, AKT1, and PIK3R1 in the key genes. The gene discussed is CCND1; the disease is acute monocytic leukemia.