Additionally, wogonin has been observed to inhibit tumor angiogenesis by degrading HIF‐1, inhibit the growth and formation of additional malignant tissues by inducing autophagy, apoptosis, and cell cycle arrest at G2/M in human CRC cells by the manipulation of the signal transducer markers and activation of transcription 3 (STAT3) and PI3K/AKT. Here, HIF1A is linked to neoplasm.