In vitro experiments have exhibited that wogonin inhibited NF‐kB, PI3K/Akt, MMP‐2, PI3K/Akt, Rac‐1, and ERK signaling pathways to reduce adhesion, actin remodeling in B16‐F10 melanoma cells, invasion, and cellular migration. The gene discussed is NFKB1; the disease is melanoma.