It has also been reported that wogonin can reduce the extent of expression of CDK‐9 and Mcl‐1 in the melanoma cells SK‐MEL‐37 to overcome the resistance of TRAIL proteins, can decrease MDM2 and c‐FLIP protein levels while raising p53 and TRAIL‐R2 protein levels. Here, TNFRSF10B is linked to melanoma.