BECN1 and colorectal carcinoma: The following hypotheses can be tested: first, by investigating whether HMGB1 induces autophagy after IR in CRC cells; second, by investigating whether BECN1 translocates to the cytoplasm after IR; and finally, by determining whether HMGB1 promotes autophagy by binding to BECN1 in the cytoplasm of CRC cells.