CXCL13 and systemic lupus erythematosus: In particular, specific neutralization of CXCL13 with anti-CXCL13 antibody can effectively decrease the Th17/Treg ratio in spleen, therefore alleviating kidney damage in MRL/lpr mice, which is a well-studied animal model for lupus and a generally accepted spontaneous model of LN (18, 19).