Interestingly, further experiments showed significant differences in the percentage and absolute number of CD4+CXCR5+ T cells and CD8+CXCR5+ T cells in the blood circulation of non-LN patients and LN patients, suggesting the potential of CXCR5+ T cells in differentiating patients with LN (Figure 5B). The gene discussed is CXCR5; the disease is lobular neoplasia.