CXCL13 and lobular neoplasia: Results demonstrated that serum CXCL13 levels exhibited statistically consistent and significant correlations with key clinical parameters of LN, including complement C3, serum Alb and Hb: (1) serum CXCL13 was negatively correlated with the level of complement C3, suggesting that its elevated levels may exacerbate complement depletion and aggravate disease severity (Figure 4B).