VLDLR and neoplasm: Excess circulating cholesterol and triglycerides are taken up by tumor cells via low-density lipoprotein receptor (LDLR) or scavenger receptor Scavenger Receptor Class B Type 1 (SR-B1), thereby activating the PI3K/AKT/mTOR signaling pathway and boosting tumor cell proliferation and anti-apoptotic capabilities (142).