Cholesterol metabolic intermediates, such as oxysterols (e.g., 27-hydroxycholesterol), induce epithelial-mesenchymal transition (EMT) in CRC cells by binding to estrogen receptor α (ERα) or liver X receptor (LXR), thereby enhancing their invasiveness and promoting hepatic metastatic colonization (143). This evidence concerns the gene ESR1 and colorectal carcinoma.