A full network of interactions between PA and human host proteins (Figure 2) enabled us to reveal the overall cell response to infection, digging up also new possible pathogenic mechanisms: the modulating effect of outer membrane proteins oprH, oprQ, and the elastase lasB on Complement Cascade Pathway (Reactome R-HSA-166658; 18/55; FDR < 0.0001%) for contrasting bacterial cell damage. The gene discussed is ALB; the disease is infection.