In summary, this study preliminarily suggests that among people with HIV, dyslipidemia—as indicated by elevated serum triglyceride (TG) levels—and a hypercoagulable state, reflected by increased fibrinogen degradation products (FDP) and prothrombin activity (PTA), may be associated with a higher risk of non-traumatic osteonecrosis of the femoral head (NONFH). This evidence concerns the gene F2 and familial avascular necrosis of femoral head.