As shown in Figure 2A, we directly co-injected 4 × 104 LLC cells into the left lung of C57BL6 mice with medium alone, 4 × 104 fibroblasts from the control PBS lung, and 4 × 104 fibroblasts from the BLM-induced IP lung environment after dividing the mice into three groups (LLC-only, PBS-fibroblast, and BLM-fibroblast groups). The gene discussed is BLM; the disease is Bloom syndrome.