The results showed that pathways related to DNA replication and the cell cycle were enriched in the C2 group, with significant upregulation of proliferation and metabolism-related pathways, such as the p53 and PI3K/Akt pathways (Figures 3D, E), and the above findings suggested that patients with stronger proliferative capacity of AML cells tend to have a poorer prognosis (14, 15). Here, TP53 is linked to acute myeloid leukemia.