Making a decision on relapse in patients with anti-LGI1 encephalitis may be complicated because relapses are not always accompanied by clinical or laboratory signatures that are pathognomic to anti-LGI1 encephalitis, such as FBDS, increased T2/FLAIR signals in the medial temporal lobes, or an increase in LGI1 antibody titers. The gene discussed is LGI1; the disease is viral encephalitis.