Common non-invasive circulating markers of inflammation include neutrophil-to-lymphocyte ratio and C-reactive protein-to-albumin ratio, and the elevation of these ratios not only predicts an increase in the severity of coronary heart disease, but also serves as an independent early warning signal of poor prognosis in patients experiencing ST-segment-elevation myocardial infarction, a finding that has been confirmed in several studies (17, 18). The gene discussed is ALB; the disease is coronary artery disorder.