This investigation utilized a retrospective cohort methodology to ascertain and compare serum procalcitonin (PCT) and C-reactive protein (CRP) concentrations among a pediatric population comprising 29 individuals diagnosed with septic arthritis and 25 with non-septic arthritis (NSA), all of whom were admitted to our institutional facility over a three-year period from 2019 to 2021. The gene discussed is CRP; the disease is bacterial arthritis.