Baseline eGFR increased with cumulative MetS components (ANOVA P = .0002) and correlated significantly with waist circumference (r = 0.39, P < .0001), high-density lipoprotein cholesterol (r = −0.38, P < .0001), Si-clamp (r = −0.22; P = .003), and insulin secretion (r = 0.22; P = .0003). This evidence concerns the gene INS and metabolic syndrome.