INS and prediabetes syndrome: In a Cox proportional hazards regression model, higher baseline eGFR was associated with lower risk of incident prediabetes: hazard ratio (HR) 0.986 [95% confidence interval (CI) 0.975-0.997, P = .012], adjusted for age at enrollment, sex, race/ethnicity, and baseline values for BMI, waist circumference, FPG, 2hPG, insulin sensitivity, insulin secretion, and uACR (Table 5).