IL1B and serum lipopolysaccharide activity: Immunoregulatory function of D‐mannose has been later documented by Torretta et al., to involve suppression of macrophage production of IL‐1β by accumulated intracellular M6P impairing the glucose utilization, which contributed to alleviation of lipopolysaccharide (LPS)‐induced endotoxemia and dextran sulfate sodium (DSS)‐induced colitis in mice [29].