Moreover, multiple T cell subsets (e.g. CD4_Th1, MAIT, CD8_Effector‐GZMK(+) etc.)showed markers of T cell exhaustion in patients with severe coinfection, which was evidenced by: (i) elevated inhibitory molecules such as PDCD1, HAVCR2, LAG3 etc. and (ii) elevated exhaustion‐associated TFs (PTPN6, PRDM1 etc.). This evidence concerns the gene PTPN6 and coinfection.