Chronic damage to AF (e.g., age-related collagen degradation and repeated microinjury) leads to the release of inflammatory factors (e.g., IL-1β and TNF-α), matrix-degrading enzymes (e.g., MMPs) and the degradation of cartilage oligomeric matrix protein (COMP) [7], which accelerates the decomposition of IVD stroma (e.g., proteoglycans and collagen), increases type I collagen and decreases type II collagen, while the water content of AF and NP gradually decreases, the NP loses its elasticity, and cracks appear in the AF. This evidence concerns the gene COMP and atrial fibrillation.