Specifically, obese PCOS (cases group) had significantly lower sex hormone-binding globulin (SHBG) and High-Density Lipoprotein Cholesterol (HDLC) levels, but the levels of triglyceride, leptin, fasting insulin, low density lipoprotein cholesterol and free testosterone levels were significantly higher with normal weight PCOS adolescents (6). The gene discussed is LEP; the disease is polycystic ovary syndrome.