AR and androgen insensitivity syndrome: Androgen insensitivity syndrome (AIS) (OMIM#300068) is a rare X-linked recessive disorder caused by mutations in androgen receptor (AR) gene located on chromosome Xq1.1-1.2, which results in impairment of pre- and postnatal masculinization and female phenotype albeit with a male chromosomal karyotype (1–3).