Coburger et al found that iMRI resulted in lower sensitivity (0.41) in detecting residual tumor compared with sensitivity using 5-ALA (0.85; P < .001),22 conflicting with the results of the study by Gessler et al (75% with iMRI vs 70% with 5-ALA, P not significant; Figure 4).24 iMRI did not demonstrate a significant correlation with results of histopathological confirmation including Ki-67 index and vascular proliferation (P = .112 using Spearman rho test), whereas a significant correlation could be demonstrated with 5-ALA (P = .032). The gene discussed is MKI67; the disease is neoplasm.