ENCODE ChIP-seq screening of DEGs in KI/KI mutants revealed significant enrichment for YY1 (Yin Yang 1) binding sites (p = 2.07 × 10−12; FDR = 3.8 × 10−11; OR = 1.532), with specificity to SK-N-SH neuroblastoma cells. Here, PSME3 is linked to neuroblastoma.