Key criteria include gastrointestinal symptoms (nausea/vomiting), abdominal pain, encephalopathy, elevated bilirubin, leucocytosis, elevated liver enzymes such as aspartate transaminase/ alanine transaminase (AST/ALT), elevated creatinine, prolonged prothrombin time (PT)/activated partial thromboplastin time (APTT), ultrasound findings (hepatic steatosis). The gene discussed is GPT; the disease is fatty liver disease.