For instance, in glioma, oxylipin 5-hydroxyeicosatetraenoic acid (5-HETE) promoted M2-like macrophage polarization and PD‐L1 upregulation via the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, leading to immunosuppressive TME.205. The gene discussed is NFE2L2; the disease is central nervous system cancer.