Functionally, LRI‐201 inhibited LIF/LIFR interaction in an AlphaScreen assay with an IC50 of 21.92 ± 2.16 μM and effectively reversed LIF‐induced proliferation, epithelial–mesenchymal transition (EMT), and capecitabine resistance in MKN45 GC cells [37]. The gene discussed is LIFR; the disease is gastric cancer.