Lung squamous cell carcinoma (LUSC) represents a glycolysis‐predominant subtype, characterized by high expression levels of glucose transporter 1 (GLUT1), hexokinase 2 (HK2), and lactate dehydrogenase A (LDHA), as well as strong FDG uptake on PET imaging [22, 23]. Here, HK2 is linked to squamous cell lung carcinoma.