Tumor cells increasingly rely on de novo fatty acid synthesis, supported by key enzymes such as ATP citrate lyase (ACLY), acetyl‐CoA carboxylase (ACC1), fatty acid synthase (FASN), and stearoyl‐CoA desaturase 1 (SCD1), which together promote membrane biogenesis, signaling, and energy supply. This evidence concerns the gene ACLY and neoplasm.