AMACR and neoplasm: Metabolomic profiling of RM-1/CXCR2 tumours revealed elevated palmitic acid and ω−3/ω−6 very-long-chain polyunsaturated fatty acids (VLC-PUFAs) in the TME (Supplemental Fig. 7B–C), and TAMs exhibited significantly greater lipid uptake than did spleen-derived macrophages (Fig. 5D).