Our previous work revealed that IL-8/CXCR2 activation orchestrates a triad of immunosuppressive events: (i) tumour-infiltrating regulatory T-cell (Treg) recruitment, (ii) CD8+ T-cell exhaustion, and (iii) M2-like tumour-associated macrophage (TAM) polarization [5]– [6], which are effects partially mediated by metabolic reprogramming. The gene discussed is CD8A; the disease is neoplasm.