ELISAs revealed that CXCL15 secretion within the TME increased significantly with tumour growth in both the RM-1 and RM-1/CXCR2 models, peaking at approximately Day 10, whereas the intracellular CXCL15 levels remained unchanged (Fig. 5B–C). The gene discussed is CXCR2; the disease is neoplasm.