Functional pathway enrichment analysis indicates that the downregulation of these miRNAs likely leads to the activation of critical signaling pathways associated with sustaining proliferative signaling, estrogen receptor (ESR1)/ERBB-positive luminal breast cancer, ESR1 signaling, and JNK/MAPK signaling (Fig. 1E, upper panel). This evidence concerns the gene ESR1 and breast carcinoma.