Among the top 10 associations, immune system and BBB-related biomarkers (e.g., selenoprotein S, red blood cell distribution width, PDZK1-interacting protein 1) were inversely associated with AD pathology, while lipid traits like LDL cholesterol and total fatty acid levels were positively linked to AD phenotypes. The gene discussed is PDZK1IP1; the disease is Alzheimer disease.