Notably, several BBB-related biomarkers, such as cation-independent mannose-6-phosphate receptor, neutrophil collagenase, and potassium voltage-gated channel subfamily E member 2, along with immune-related biomarkers like FSC-A on plasmacytoid dendritic cell and HLA DR on myeloid dendritic cell, were significantly associated with LOAD and AD proxy (Table S1). This evidence concerns the gene KCNE2 and Alzheimer disease.