MAPT and Alzheimer disease: Regarding pathway profiles, PWY-7328 (the superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis) was reversely associated with both LOAD and AD proxy, while PWY0-1061 (the superpathway of L-alanine biosynthesis) was positively correlated with CSF Aβ42 levels and reversely associated with CSF p-tau levels, suggesting a potential link to reduced AD risk.