Lipid traits, including LDL cholesterol (β = 0.199, P < 0.0001) and total cholesterol minus HDL-C (β = 0.17, P = 0.0011), were positively correlated with CSF p-tau levels, while remnant cholesterol (non-HDL, non-LDL cholesterol) was reversely correlated with AD proxy (β = −0.26, P < 0.001). Here, MAPT is linked to Alzheimer disease.