Consistently, circAass overexpression ameliorated inflammation (Figure 8(F,G)) and tubulointerstitial fibrosis (Figure 8(H,I); Figure S7D, E), decreased pro-fibrotic molecules (ACTA2/αSMA, FN1 and COLIA) (Figure 8(J-M); Figure S7F-I) and improved renal function in I/R-AKI (Figure 8(N)) and CP-AKI mice. This evidence concerns the gene ACTA2 and acute kidney injury.