To determine whether the differences observed between p21+ and p16+ cell populations during aging are specific to age-related senescence or also occur in disease contexts, we compared our results with a mouse model of metabolic dysfunction-associated steatohepatitis (MASH) (Bendixen et al, 2024), a condition characterized by elevated senescence markers (Yashaswini et al, 2024) (Fig. EV8A–C). The gene discussed is CDKN1A; the disease is metabolic dysfunction-associated steatohepatitis.