Therefore, Cluster 2, which was characterised by high ETS1 and low EFNA4 expression, showed an increase in cell subpopulations related to immune suppression, such as naïve B cells, memory B cells, resting dendritic cells, and resting mast cells, which are typically associated with a weaker immune response and may facilitate tumour immune evasion. This evidence concerns the gene ETS1 and neoplasm.