While some studies investigating the association between EGFR mutations and self-reported race were negative27, these were likely underpowered to identify differences in genes with rare mutation frequencies such as EGFR. Interestingly, one case study revealed a rare germline EGFR variant in a Chinese family with two prostate cancer cases associated with biallelic CDK12 inactivation28. This evidence concerns the gene CDK12 and prostate cancer.