PDE5A and cancer: However, when we divided into EUR and non-EUR individuals, we observed multiple differences between the two groups: while cancer history, sex, daily alcohol intake, smoking daily, and longitude were significant for both, the other SDOH and lifestyle factors, the two ﻿PDE5a inhibitors (sildenafil: p = 45e-6; and tadalafil: p = 2.7e-4) and genotype PC2 were significant only for individuals of European ancestries, whereas genotype PC1 and genotype PC3 were significant only for individuals of non-European ancestries (Fig. 4E, F, Table S4).