Removing eight of the risk variables (sex, cancer history, SDOH, lifestyle, genotype PCs, geo = longitude and latitude, ﻿PDE5a inhibitors, and predicted ancestry) one at a time from the XGBoost multiethnic model had minimal effects on its accuracy (mean F1 statistic = 0.807 across eight variables, Fig. S6, Table S7). Here, PDE5A is linked to cancer.