ATF6 and glaucoma: Intriguingly, a trend toward reduced expression of NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3), a marker of inflammation, was observed in mt-EcGAPR mice compared with that in C57BL/6 J control mice, although the difference was not statistically significant, suggesting the dominance of the ER stress–ATF6–pyroptosis axis in the early stages of glaucoma (Supplementary Fig. 7h, i).