Through proteomic profiling, we identified 79 differentially expressed proteins (|fold change (FC)| > 1.3, P < 0.05) in lesional skin between Lztr1-deficient and control (Lztr1fl/fl) mice, including decreased expression of several hallmark psoriasis genes, such as S100a8, S100a9, Lcn2, and Il1a, in Lztr1-deficient mice (Fig. 2h), along with normalization of epidermal keratin and differentiation markers (keratin 14 (K14), keratin 10 (K10) and filaggrin (Flg)) (Fig. 2h, i). The gene discussed is FLG; the disease is psoriasis.