We demonstrated that depletion of CD8+ T cells ameliorates the disease severity in control mice, while abolishing CD8+ T in Lztr1-deficient mice had no additive impact on disease severity (as measured by PASI) (Fig. 4j, k), epidermal thickness (Fig. 4l, m), inflammatory response (Fig. 4n, p, q), or hyperkeratosis (Fig. 4o, q). The gene discussed is CD8A; the disease is Hyperkeratosis.