CXCL8 and psoriasis: This cluster not only exhibited enrichment of well-established psoriasis risk genes, such as SERPINB4, IL36G, and CARD1414,32, but also included a previously less recognized gene, LZTR1. Notably, high expression levels of LZTR1 were associated with increased expression of chemokines, including CXCL1, CXCL8, and CCL20, within Cluster 9 (Supplementary Fig. S1k, l).