To further support that LZTR1high KCs represent a distinct subset of epidermal KCs, we analyzed additional scRNA-seq data and observed a significant increase in LZTR1 expression in psoriatic KCs (Supplementary Fig. S3a), which was further validated in two published bulk RNA-seq datasets by comparing LZTR1 mRNA expression between lesional and non-lesional skin samples (Supplementary Fig. S3d). Here, TBCE is linked to dry eye syndrome.