Through proteomic profiling, we identified 79 differentially expressed proteins (|fold change (FC)| > 1.3, P < 0.05) in lesional skin between Lztr1-deficient and control (Lztr1fl/fl) mice, including decreased expression of several hallmark psoriasis genes, such as S100a8, S100a9, Lcn2, and Il1a, in Lztr1-deficient mice (Fig. 2h), along with normalization of epidermal keratin and differentiation markers (keratin 14 (K14), keratin 10 (K10) and filaggrin (Flg)) (Fig. 2h, i). Here, S100A8 is linked to psoriasis.