LZTR1 and cancer: Leucine zipper-like transcription regulator 1 (LZTR1), a substrate adaptor for cullin3 (CUL3) ubiquitin ligase complex, has been reported as a regulator of RAS/MAPK signaling to control cancer progression23,24, and as a candidate oncogene in melanoma25, indicating the heterogeneity of LZTR1 function in different disease conditions.