Lastly, to determine if this was dependent upon the function of LZTR1 in KCs, we crossed Lztr1fl/fl mice with Lysozyme 2-Cre (Lyz2Cre/+) mice to specifically delete Lztr1 gene in professional antigen-presenting cells but did not find differences in inflammatory responses between Lztr1fl/fl mice and Lyz2Cre/+Lztr1fl/fl mice (Supplementary Fig. S12a–c), suggesting that the antigen presentation function of KCs affects the CD8+ T cells in psoriasis lesions. Here, CD8A is linked to psoriasis.