To determine the interactome of LZTR1 in cells, we performed a mini-TurboID proximity biotinylation-based experiment on YUSIK, a melanoma cell line, based on our preliminary work25 (Supplementary Fig. S14e, f), and FLAG tag-based or LZTR1 antibody-based coimmunoprecipitation (co-IP) experiments on HaCaT, followed by liquid chromatography coupled to mass spectrometry (LC-MS). This evidence concerns the gene LZTR1 and melanoma.