However, our results showing improvements in KIM‐1 levels suggest an essential role for mitochondrial function/ROS production in proximal tubular cells as an important mechanism(s) driving the beneficial effects of UNI‐494; results that are consistent with previous observations, including improved uNGAL levels following treatment with UNI‐494 in an AKI model. The gene discussed is HAVCR1; the disease is acute kidney injury.