CREB1 and systemic lupus erythematosus: Previous studies have demonstrated that Qihuang Jianpi Zishen Granules (QJZG) can reduce the levels of various inflammatory cytokines, improve immune regulation and exert therapeutic effects on SLE-induced renal damage.2, 4 Previous animal studies have demonstrated that QJZG mitigates the proliferation of SLE mesangial cells by modulating the GAS5/miR-21/SIRT1 axis and suppressing the ERK/CREB pathway.5