Here, we found that ketone body metabolism was impaired in both human scars and bleomycin (BLM)-induced skin fibrogenesis of mice by bioinformatics analysis, which was further evidenced by downregulated expression of key modulators of ketone metabolism, including BDH1 (3-hydroxybutyrate dehydrogenase 1), OXCT1 (3-oxoacid CoA-transferase 1), and ACAT1 (acetyl-CoA acetyltransferase 1). This evidence concerns the gene BDH1 and neoplasm.