Up to this point, the majority of research investigating the link between obesity and cancer has concentrated largely on the role of adipokines released from adipose tissue and their impacts on the immune system.[10, 62, 63] However, our groundbreaking findings shed light on the critical FA‐HIF‐1α‐CCL2 axis in obesity‐related cancer, providing a novel perspective. The gene discussed is HIF1A; the disease is obesity due to melanocortin 4 receptor deficiency.