HIF1A and cancer: In the hypoxic TME, HIF‐1α undergoes stabilization, triggering the expression of genes that drive angiogenesis, erythropoiesis, metabolism, cell proliferation, and overall survival.[39, 40, 41, 42] The overexpression of HIF‐1α across various cancers has become a concerning marker, often correlating with poor patient prognosis.[43, 44, 45] Recent studies have revealed a striking connection between excessive FAs within the TME and the activation of HIF‐1α.