Moreover, HIF‐1α is recognized for its role in regulating metabolic pathways and inflammatory responses as a transcription factor for important cytokines, including CCL2, CCL5, CCL7, IL‐6, and VEGF.[18, 19, 20, 21] Building on this foundation, we focused our investigation on identifying the specific cytokines influenced by HIF‐1α in the context of obesity and elevated FA levels. Here, CCL5 is linked to obesity due to melanocortin 4 receptor deficiency.