AKT1 and cancer: Specifically, high levels of FAs stimulate the phosphorylation of AKT and mTOR‐key signaling pathways that enhance HIF‐1α translation.[15, 16, 46, 47] Our research has compellingly demonstrated that an increased availability of FAs significantly elevates HIF‐1α expression in cancer cells under obese conditions, both in vivo and in vitro.