This innovative design allows for optimal oxygen supply through the bottom of each well, as previously detailed in our study (Figures 2, 5; Figure S3D, Supporting Information).[15, 16] We found that CCR2 expression is increased in peritumoral adipose tissue of obese cancer patients, suggesting it is affected by CCL2 from the tumor (Figure 3C; Figure S3H, Supporting Information). This evidence concerns the gene CCL2 and cancer.