Among candidate transcription factors, the expression levels of osterix (OSX), Runt‐related transcription factor 2 (RUNX2), Special AT‐rich sequence‐binding protein 2 (SATB2), and distal‐less homeobox 5 (DLX5) were higher in the shRNA‐OM group than in the control‐OM group. This evidence concerns the gene DLX5 and ocular melanoma.