The expression level of Smad6 was significantly higher in the shDRG2‐OM than the control‐OM on day 3 and day 7 (day 3, p < 0.0001; day 7, p < 0.001) and was significantly higher on day 3 and day 7 (p < 0.05) (Figure 4a). The gene discussed is SMAD6; the disease is ocular melanoma.